• CORT induced hippocampal damage has been implicated

  2023-08-03

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

• Most clinically approved antiangiogenic drugs are

  2023-08-03

  

  Most clinically approved antiangiogenic drugs are aimed at blocking the action of vascular endothelial growth factor, or VEGF, which is accepted to be the most important tumor-derived angiogenic factor, stimulating proliferation and migration of endothelial cells, as well as branching of vessels (Fe

• The radiographic correlate will be similarly

  2023-08-03

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary cgrp antagonist receptor neoplasms. It has been reported that icotinib and gefitinib, epidermal growth f

• br Conclusions Our study confirms

  2023-08-02

  

  Conclusions Our study confirms that N-terminal mutations can affect Aβ fibril and oligomer formation, despite lying outside the core amyloid region of Aβ. Of the three factors that may influence Aβ-mediated toxicity (primary structure of Aβ, assembly structure and cellular responses), our results

• Aerobic exercise plays an important role in

  2023-08-02

  

  Aerobic exercise plays an important role in the regulation of (±)-Baclofen metabolism in the skeletal muscle. It is also associated with increases in AMPK and GLUT4 levels, resulting in the improvement of the glucose uptake signaling pathway [17,18]. Recently, it has been shown that exercise marked

• Interestingly metabolic dysfunction is also observed in amyo

  2023-08-02

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting casein kinase expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) found that reducing AM

• Sixth significant progress has been made during the last

  2023-08-02

  

  Sixth, significant progress has been made during the last few years regarding the molecular mechanisms underlying the activation of AMPK and this should aid to develop more potent and specific compounds. Information from crystallographic structures combined with computer-based drug design hold promi

• br A and tau in Alzheimer s disease

  2023-08-02

  

  Aβ and tau in Alzheimer's disease The two classical histopathological hallmarks of AD are extracellular insoluble Aβ deposits, known as Aβ plaques, and intracellular accumulations of insoluble microtubule-associated tau protein, known as neurofibrillary tangles [14]. Aβ peptides are produced as a

• 2595 NLX a k a F or befiradol exhibits

  2023-08-02

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in 2595 to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionally, it has show

• The ARHL locus ahl that

  2023-08-02

  

  The ARHL locus (ahl) that contributes to the hearing loss in the C57BL/6J mouse has been mapped to chromosome 10 (Erway et al., 1993, Johnson et al., 1997). It has been shown that strains susceptible to early onset ARHL carry a specific mutation in the cadherin 23 gene (Cdh23), which encodes a compo

• The use of a single well identified

  2023-08-01

  

  The use of a single well-identified molecule to induce AChR clusters formation can simplify complicated cell manipulation procedures and may provide a more efficient means of developing biological substitutes for functional muscle tissue restoration in vivo. Pharmacological approaches dealing with b

• In summary the role of HT and

  2023-08-01

  

  In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,

• LX7101 HCL australia br Cytochrome b br Cytochrome

  2023-08-01

  

  Cytochrome b5 Cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1) A number of P450s involved in steroid biosynthesis are multifunctional as they carry out two or more sequential hydroxylation reactions on the same substrate(s). P450 17A1 is a dual function endoplasmic reticulum enzyme enco

• br Autophagy and cell death pathways in ischemic

  2023-08-01

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Cy5 TSA Fluorescence System Kit injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great

• NOXA a member of the pro apoptotic B cell lymphoma

  2023-08-01

  

  NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In

16151 records 316/1077 page Previous Next First page 上5页 316317318319320 下5页 Last page