• br Acknowledgements br Funding This work was supported

  2021-10-26

  

  Acknowledgements Funding: This work was supported by the Instituto Nacional de Biomedicina do Semiárido (INCT-IBISAB-CNPq), Edital MCT/CNPq N° 014/2010 - Universal and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Introduction Guanylin and uroguanylin are small, heat-

• Studies of human and mouse GPR as

  2021-10-26

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl

• While PLGA implants could be beneficial for regenerative

  2021-10-26

  

  While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they tcY-NH2 sale could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which might ha

• The diseases of ocular surface and

  2021-10-26

  

  The diseases of ocular surface and the cornea are very common in ophthalmological practice and as a result there is a continuous, need for novel therapeutic options. Here, we demonstrated a corneal distribution of GPR35, a potential molecular target for new drugs (; ). The search for the expression

• Xie et al b reported that the combination of

  2021-10-26

  

  Xie et al. (2009b) reported that the combination of diagnostic ultrasound impulses and cyclic RGD-bearing MBs targeted for GP IIb/IIIa resulted in the successful recovery of epicardial and microvascular blood flow in swine models with acute thrombotic occlusion. It is well known that the stability o

• Exo1 br Investigations br Genetics GLUT is a membrane bound

  2021-10-26

  

  Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, Exo1 microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, located on chromosome

• CC is a widespread disorder

  2021-10-25

  

  CC is a widespread disorder affecting up to 20% of people worldwide, which also deteriorates the quality of life of patients and causes a substantial economic burden to society. There are 3 categories of CC: normal-transit constipation, slow-transit constipation and defecatory or rectal evacuation d

• We have expanded these studies

  2021-10-25

  

  We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA CCG 203971 or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antagonis

• br Introduction Histamine stored in

  2021-10-25

  

  Introduction Histamine stored in mast cells and basophils has been recognized as one of the most critical mediators in allergic reactions and plays an important role in eliciting the nasal symptoms of allergic rhinitis, such as sneezing, nasal itch, pain, rhinorrhea, and congestion [1], [2]. It i

• Introduction Multiple sclerosis MS a

  2021-10-25

  

  Introduction Multiple sclerosis (MS), a neurological autoimmune disease, is driven by CD4+ AST 487 of the T helper (TH) cells [1]. There is no curative treatment for MS and the present treatments typically focus on immunomodulation for slowing the progression of the disease. These includes interfer

• br FFA GPR was deorphanised as

  2021-10-25

  

  FFA4 GPR120 was deorphanised as the second receptor for long-chain fatty acids in 2005 [5]. Initial focus highlighted expression in the lower gut, the capacity of unsaturated fatty acids to promote release of the incretin glucagon-like peptide-1 (GLP-1) from the enteroendocrine cell line STC-1, a

• The GLU Epac transgenic mouse enabled us to monitor

  2021-10-25

  

  The GLU-Epac transgenic mouse enabled us to monitor cAMP responses to GPR119 ligands in individual primary cultured L-cells. Not all L-cells were found to be responsive to AR231453, suggesting there may be a subpopulation of L-cells that do not express functional GPR119. There was a tendency for sma

• There were significant differences in mRNA

  2021-10-25

  

  There were significant differences in mRNA expression levels observed for 7 out of 15 analyzed genes. This observation suggests, that selection of a reference/control group may influence interpretation of gene expression studies performed in liver pathologies. This study directly evidenced that anal

• To examine the possible role of

  2021-10-25

  

  To examine the possible role of mGluRs in the LH/PFA in the hypercapnic ventilatory response, a nonspecific antagonist of mGluRs, MCPG, was microinjected into the LH/PFA. MCPG elicited a significantly increased hypercapnic ventilatory response in awake rats, but not during sleep, in the light and da

• Instead our results reveal that autophagy controls the membr

  2021-10-25

  

  Instead, our results reveal that autophagy controls the membrane association of the cargo-selective SNX-BAR retromer assembly (comprised of the VPS35/29/26 trimer in association with SNX1/2 and SNX5/6), which has been demonstrated to promote GLUT1 surface recycling. Accordingly, GLUT1 localization i

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